Cardinals vs. 49ers history: Arizona struggling in recent meetingsJess Root, The Arizona Cardinals will face the San Francisco 49ers on Sunday on the road. They have not had a ton of recent success against the 49ers. They lost to them in both meetings last season and are 2-6 in their last eight against them. The 49ers lead the all-time series 38-31. The Cardinals had an 8-0 run from 2015-2018, but the Niners have won nine of the last 14 meetings since.
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